The Urinary Stone Disease Research Network (USDRN) is a group of scientists and investigators designing and conducting research on urinary stones (kidney stones) in adults and children in order to learn more about

  • who forms kidney stones,
  • what are the best treatments,
  • how to prevent stones from forming.

Funded by the National Institutes of Health (NIH) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the network comprises a wide range of experts including adult and pediatric urologists, adult and pediatric nephrologists (kidney specialists), pediatricians, emergency department physicians, clinical trialists, nutritionists, behavioral scientists, and radiologists.

The Duke Clinical Research Institute is the USDRN Scientific Data Research Center and four clinical sites are conducting the studies:

  • University of Pennsylvania/Children's Hospital of Philadelphia
  • University of Texas Southwestern Medical Center
  • University of Washington
  • Washington University in St. Louis

The coordinating center and clinical sites work together in planning, executing, and analyzing the results from USDRN studies.


As Kidney Stones Increase, Researchers Turn to Technology for Answers

NIH-funded study investigates utility of smart water bottle to reduce the risk of kidney stones

DURHAM, N.C. (March 8, 2018)—Newly published research shows that kidney stones doubled in men and quadrupled in women between 1984 and 2012 (Kittanamongkolchai et al., 2018). As experts scramble for answers on how to quell this unwelcome spike, researchers with the Prevention of Urinary Stones with Hydration (PUSH) study have been testing their own hypothesis for several months; namely, that a high-tech water bottle might be one key to reducing the recurrence of the urinary stone disease, commonly referred to as kidney stones.


Direct charges infographic


Since 1994, the number of people who get kidney stones has almost doubled! The number has risen from 1 out of every 20 people, to now 1 out of every 11 people. This increase is likely due to diet and lifestyle factors. Obesity also increases the risk of having a kidney stone.

Kidney stones are more common in men than women, while less common in people who are Hispanic and African-American.

Infographic of incidence